Panajachel [1] is one of Guatemala’s best places to shop for handicrafts with several stores along Calle Santander. Stalls also line the street jam-packed with goods from wall to wall. Street sellers expect you to bargain.
Start at about half the asking price and work your way up from there. There are some nice, though somewhat pricier, shops in the small Centro Comercial Siquín on Calle Santander across the street from El Bistro.
Links:
[1] http://www.moon.com/destinations/guatemala/the-western-highlands/panajachel-and-lake-atitlan