Live music venues are few and far between in the Russian River [1] region. But for big shows, you can get tickets for the Wells Fargo Center for the Arts (50 Mark West Springs Rd., Santa Rosa, 707/546-3600, http://wellsfargocenterarts.org [2], ticket prices vary by show). This full-sized theater hosts any number of national acts each year (plus the occasional play or headlining comic)
You might see Melissa Etheridge, the Beach Boys, or Donna Summer at this Santa Rosa concert hall.
Links:
[1] http://www.moon.com/destinations/california/wine-country/russian-river-valley
[2] http://wellsfargocenterarts.org