One of the more accessible and enjoyable resort-type stays in the Charleston [1] area is on the Isle of Palms at Wild Dunes Resort (5757 Palm Blvd., 888/778-1876, www.wilddunes.com [2], $254–320). This is the place to go for relaxing, beach-oriented vacation fun, either in a traditional hotel room, a house, or a villa. Bustling Mount Pleasant is only a couple of minutes away and Charleston proper not much farther.
Links:
[1] http://www.moon.com/destinations/charleston-savannah/charleston
[2] http://www.wilddunes.com