While industry is coming quickly to Liberty County [1], it’s still a small, self-contained community with not much in the way of tourist amenities (many would say that is part of its charm).
A great choice for a stay is 
Dunham Farms (5836 Islands Hwy., 912/880-4500, www.dunhamfarms.com [2]). The B&B ($165–205) is in the 1940s converted Palmyra Barn, and the self-catered circa-1840 Palmyra Cottage ($300) nearby is right on the river, with plenty of kayaking and hiking opportunities. Your hosts, Laura and Meredith Devendorf, couldn’t be more charming or informed about the area, and the breakfasts are absurdly rich and filling in that hearty and deeply comforting Southern tradition.
Restaurants of note include the Sunbury Crab Company (541 Brigantine Dunmore Rd., 912/884-8640, lunch Sat.–Sun., dinner Wed.–Sun., $10–30), providing, you guessed it, great crab cakes in a casual atmosphere on the Midway River. Get there by taking GA 38 east of Midway and then a left onto Fort Morris Road.
Many locals eat at least once a week at Holton’s Seafood (13711 E. Oglethorpe Hwy., 912/884-9151, daily lunch and dinner, $7–17), an unpretentious and fairly typical family-run fried seafood place just off I-95 at the Midway exit.
Links:
[1] http://www.moon.com/destinations/charleston-savannah/savannah/outside-savannah/liberty-county
[2] http://www.dunhamfarms.com