A short ways out of Walterboro [1] in the opposite direction of the Tuckegee Airmen Memorial [2] is the Great Swamp Sanctuary (www.thegreatswamp.org [3], daily dawn–dusk, free), a still-developing ecotourism project focusing on the Lowcountry environment. Located in one of the few braided-creek habitats accessible to the public, the 842-acre Great Swamp Sanctuary has three miles of walking and biking trails, some along the path of the old Charleston-Savannah stagecoach route.
Kayakers and canoeists can paddle along over two miles of winding creeks. A 10,000 square-foot interpretive center is in the works.
There are three entry points to the Great Swamp Sanctuary, all off Jefferies Boulevard. Here they are in west-to-east order from I-95: north onto Beach Road, north onto Detreville Street (this is considered the main entrance), and west onto Washington Street.
Links:
[1] http://www.moon.com/destinations/south-carolina/beaufort-and-the-lowcountry/walterboro
[2] http://www.moon.com/destinations/south-carolina/beaufort-and-the-lowcountry/walterboro/sights/tuskegee-airmen-memorial
[3] http://www.thegreatswamp.org