If you’re looking for big-box lodging, the section of Walterboro [1] close to I-95 is absolutely chock-a-block with it. The quality is surprisingly good, perhaps because they tend to cater to northerners on their way to and from Florida.
A good choice is Holiday Inn Express & Suites (1834 Sniders Hwy., 843/538-2700, www.hiexpress.com [2], $85), or try the Comfort Inn & Suites (97 Downs Lane, 843/538-5911, www.choicehotels.com [3], $95).
If you’d like something with a bit more character, there are two B&Bs on Hampton Street downtown. Old Academy Bed & Breakfast (904 Hampton St., 843/549-3232, www.oldacademybandb.com [4], $80–115) has four rooms housed in Walterboro’s first school building. They offer a full Continental breakfast. Note that credit cards are not accepted!
Though built recently by local standards, the 1912 Hampton House Bed and Breakfast (500 Hampton St., 843/542-9498, www.hamptonhousebandb.com [5], $125–145) has three well-appointed rooms and offers a full country breakfast. By appointment only, you can see the Forde Doll and Dollhouse Collection, with over 50 dollhouses and oodles of antique dolls.
The story of food in Walterboro [1] revolves around 
Duke’s Barbecue (949 Robertson Blvd., 843/549-1446, $7), one of the best-regarded barbecue spots in the Lowcountry [6] and one of the top two joints named “Duke’s” in the state (the other, by common consensus, is in Orangeburg). The pulled pork is delectable, cooked with the indigenous South Carolina mustard-based sauce.
Unlike most area barbecue restaurants, some attention is devoted to the veggies, such as collard greens, green beans, and black-eyed peas with rice.
Links:
[1] http://www.moon.com/destinations/south-carolina/beaufort-and-the-lowcountry/walterboro
[2] http://www.hiexpress.com
[3] http://www.choicehotels.com
[4] http://www.oldacademybandb.com
[5] http://www.hamptonhousebandb.com
[6] http://www.moon.com/destinations/south-carolina/beaufort-and-the-lowcountry