Travelers interested in colonial architecture will not leave Chiapas  disappointed. San Cristóbal de las Casas  is easily one of Mexico’s finest colonial cities, boasting a beautiful cathedral, elegant Dominican priory and convent, and numerous well-preserved colonial-era structures. Nearby are the smaller, but no less significant, colonial towns of Comitán  and Chiapa de Corzo .
There also are a number of indigenous villages that are not colonial in an overall sense but that contain superb colonial structures, especially churches and convents. A rental car is recommended for this route, which includes leap-frogging from town to town.
Visit outlying indigenous villages known for their colonial churches, including San Juan Chamula  and Tenejapa . Time permitting, the church in Oxchuc  is also superb. (Remember that taking pictures of indigenous people or inside any of the town churches is strictly forbidden.)
Drive east toward Comitán , stopping to admire colonial churches and plazas in Amatenango del Valle , Teopisca, and Soyatitán . In the evening, enjoy a meal and live music at Comitán’s lovely central plaza .
Visit Comitán’s churches, Templo Santo Domingo de Guzmán  and Iglesia de San Caralampio , and wander the town’s carefully restored colonial neighborhoods. Stay the night, or drive to Chiapa de Corzo .
Take a tour of Cañón del Sumidero —not a colonial attraction, but a must-see nonetheless—and spend the afternoon enjoying colonial gems around Chiapa de Corzo , including La Pila , a superb 16th-century public fountain.
Get an early start on the Ruta Zoques , including stops at Chicoasén , Copainalá , and especially Tecpatán , home to one of the state’s most magnificent Dominican monasteries. Return to Tuxtla Gutiérrez  and enjoy the live music at Parque Marimba  before returning home.